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North Carolina - Science: Biology
Standard Course of Study | Adopted: 2023
1: : From Molecules to Organisms- Structures and Processes
LS.Bio.1: : Analyze how the relationship between structure and function supports life processes within organisms.
LS.Bio.1.1: : Construct an explanation to illustrate relationships between structure and function of major macromolecules essential for life.
Dehydration Synthesis
Build a glucose molecule, atom-by-atom, to learn about chemical bonds and the structure of glucose. Explore the processes of dehydration synthesis and hydrolysis in carbohydrate molecules. 5 Minute Preview
LS.Bio.1.2: : Carry out investigations to illustrate how enzymes act as catalysts for biochemical reactions and how environmental factors affect enzyme activity.
Enzymes - High School
As a veterinary technician, students learn about enzymes to help a dog that has been eating normally but is losing a lot of weight. Video Preview
LS.Bio.1.3: : Use models to explain how the structure of organelles determines its function and supports overall cell processes.
Cell Structure
Select a sample cell from an animal, plant, or bacterium and view the cell under a microscope. Select each organelle on the image to learn more about its structure and function. Closeup views and animations of certain organelles is provided. 5 Minute Preview
Cell Types
Explore a wide variety of cells, from bacteria to human neurons, using a compound light microscope. Select a sample to study, then focus on the sample using the coarse and fine focus controls of the microscope. Compare the structures found in different cells, then perform tests to see if the sample is alive. 5 Minute Preview
LS.Bio.1.4: : Construct explanations to compare prokaryotic and eukaryotic cells in terms of structures and degree of complexity.
Cell Types
Explore a wide variety of cells, from bacteria to human neurons, using a compound light microscope. Select a sample to study, then focus on the sample using the coarse and fine focus controls of the microscope. Compare the structures found in different cells, then perform tests to see if the sample is alive. 5 Minute Preview
LS.Bio.1.5: : Construct an explanation to summarize how DNA and RNA direct the synthesis of proteins.
RNA and Protein Synthesis
Go through the process of synthesizing proteins through RNA transcription and translation. Learn about the many steps involved in protein synthesis including: unzipping of DNA, formation of mRNA, attaching of mRNA to the ribosome, and linking of amino acids to form a protein. 5 Minute Preview
Protein Synthesis - High School
As a pediatrician, students learn about genes and protein synthesis to try to help a baby girl named Lucy who has an immunodeficiency disease. Video Preview
LS.Bio.2: : Analyze the growth and development processes of organisms.
LS.Bio.2.1: : Use models to illustrate how cellular division results in the reproduction, growth, and repair of organisms.
Cell Division
Begin with a single cell and watch as mitosis and cell division occurs. The cells will go through the steps of interphase, prophase, metaphase, anaphase, telophase, and cytokinesis. The length of the cell cycle can be controlled, and data related to the number of cells present and their current phase can be recorded. 5 Minute Preview
Meiosis
Explore how sex cells are produced by the process of meiosis. Compare meiosis in male and female germ cells, and use crossovers to increase the number of possible gamete genotypes. Using meiosis and crossovers, create "designer" fruit fly offspring with desired trait combinations. 5 Minute Preview
Meowsis - High School
As a geneticist in an animal hospital, students learn about genetic changes in meiosis to determine the reason why a male cat can have calico fur coloring. Video Preview
LS.Bio.3: : Analyze the relationship between biochemical processes and energy use.
LS.Bio.3.1: : Carry out investigations to explain how homeostasis is maintained through feedback mechanisms.
Homeostasis
Control a simulated person running on a treadmill. Your challenge is to use clothing, exercise, and sweat to maintain a constant body temperature as air temperature goes up and down. Sweating (perspiration) can be controlled automatically by the Gizmo or, for a challenge, manually by the user. Don't forget to eat and drink! 5 Minute Preview
Human Homeostasis
Adjust the levels of clothing, perspiration, and exercise to maintain a stable internal temperature as the external temperature changes. Water and blood sugar levels need to be replenished regularly, and fatigue occurs with heavy exercise. Severe hypothermia, heat stroke, or dehydration can result if internal stability is not maintained. 5 Minute Preview
Paramecium Homeostasis
Observe how a paramecium maintains stable internal conditions in a changing aquatic environment. Water moves into the organism by osmosis, and is pumped out by the contractile vacuole. The concentration of solutes in the water will determine the rate of contractions in the paramecium. 5 Minute Preview
Enzymes - High School
As a veterinary technician, students learn about enzymes to help a dog that has been eating normally but is losing a lot of weight. Video Preview
Homeostasis - High School
In the role of a physician assistant, students help a young man, named Anthony, who has Type II diabetes and high blood pressure. Students must make a diagnosis and then must apply the principles of filtration and homeostasis to help Anthony. Video Preview
LS.Bio.3.2: : Use models to illustrate how photosynthesis transforms light energy into chemical energy.
Cell Energy Cycle
Explore the processes of photosynthesis and respiration that occur within plant and animal cells. The cyclical nature of the two processes can be constructed visually, and the simplified photosynthesis and respiration formulae can be balanced. 5 Minute Preview
Photosynthesis Lab
Study photosynthesis in a variety of conditions. Oxygen production is used to measure the rate of photosynthesis. Light intensity, carbon dioxide levels, temperature, and wavelength of light can all be varied. Determine which conditions are ideal for photosynthesis, and understand how limiting factors affect oxygen production. 5 Minute Preview
Photosynthesis - High School
As a marine biologist students learn about photosynthesis to help scientists in Australia determine why the coral in the Great Barrier Reef is bleaching. Video Preview
LS.Bio.3.3: : Use models to illustrate how cellular respiration [aerobic and anaerobic] transforms chemical energy into ATP.
Cell Energy Cycle
Explore the processes of photosynthesis and respiration that occur within plant and animal cells. The cyclical nature of the two processes can be constructed visually, and the simplified photosynthesis and respiration formulae can be balanced. 5 Minute Preview
Cell Respiration - High School
As a medical toxicologist, students learn about cell respiration to save the life of a CIA agent that has been poisoned. Video Preview
2: : Ecosystems- Interactions, Energy, and Dynamics
LS.Bio.4: : Analyze the relationships between matter and energy within ecosystems.
LS.Bio.4.2: : Use models to explain the relationship between the flow of energy and cycling of matter among organisms in an ecosystem.
Coral Reefs 1 - Abiotic Factors
Explore the abiotic factors that affect Caribbean coral reefs. Many factors can be manipulated in this simplified reef model, including ocean temperature and pH, storm severity, and input of excess sediments and nutrients from logging, sewage, and agriculture. Click "Advance year" to see how the reef responds to these changes. 5 Minute Preview
Forest Ecosystem
Observe and manipulate the populations of four creatures (trees, deer, bears, and mushrooms) in a forest. Investigate the feeding relationships (food web) in the forest. Determine which creatures are producers, consumers, and decomposers. Pictographs and line graphs show changes in populations over time. 5 Minute Preview
Ecosystems - High School
As a national park ranger, students must restore the ecosystem of a park back to normal. They interact with populations of many organisms including wolves, deer and bees. Students learn the importance of food chains and webs, and how human factors can impact the health of an environment. Video Preview
LS.Bio.5: : Understand ecosystem dynamics, functioning, and resilience.
LS.Bio.5.1: : Use mathematics and computational thinking to explain how interactions between organisms (predator/prey, competition) affect carrying capacity and maintain stability in an ecosystem.
Coral Reefs 2 - Biotic Factors
In this followup to the Coral Reefs 1 - Abiotic Factors activity, investigate the impacts of fishing, disease, and invasive species on a model Caribbean coral reef. Many variables can be manipulated, included intensity of fishing, presence of black band and white band disease, and the presence of actual and potential invasive species. Click "Advance year" to see the impacts of these biotic changes. 5 Minute Preview
Food Chain
In this ecosystem consisting of hawks, snakes, rabbits and grass, the population of each species can be studied as part of a food chain. Disease can be introduced for any species, and the number of animals can be increased or decreased at any time, just like in the real world. 5 Minute Preview
Ecosystems - High School
As a national park ranger, students must restore the ecosystem of a park back to normal. They interact with populations of many organisms including wolves, deer and bees. Students learn the importance of food chains and webs, and how human factors can impact the health of an environment. Video Preview
LS.Bio.5.2: : Engage in argument from evidence to evaluate various solutions to reduce the impact of human activities on biodiversity and ecosystem health.
GMOs and the Environment
In this follow-up to the Genetic Engineering Gizmo, explore how farmers can maximize yield while limiting ecosystem damage using genetically modified corn. Choose the corn type to plant and the amount of herbicide and insecticide to use, then measure corn yields and monitor wildlife populations and diversity. Observe the long-term effects of pollutants on a nearby stream ecosystem. 5 Minute Preview
Nitrogen Cycle - High School
An infant on a farm has blue baby syndrome. As an EPA environmental engineer, students must find the cause of the baby's illness. Using environment data, students learn the importance of the nitrogen cycle and how human factors can impact nature. Video Preview
Photosynthesis - High School
As a marine biologist students learn about photosynthesis to help scientists in Australia determine why the coral in the Great Barrier Reef is bleaching. Video Preview
3: : Heredity- Inheritance and Variation of Traits
LS.Bio.6: : Understand genetic mechanisms for variation.
LS.Bio.6.1: : Use models to explain how DNA is passed from parents to offspring through the processes of meiosis and fertilization in sexual reproduction.
Meiosis
Explore how sex cells are produced by the process of meiosis. Compare meiosis in male and female germ cells, and use crossovers to increase the number of possible gamete genotypes. Using meiosis and crossovers, create "designer" fruit fly offspring with desired trait combinations. 5 Minute Preview
Meowsis - High School
As a geneticist in an animal hospital, students learn about genetic changes in meiosis to determine the reason why a male cat can have calico fur coloring. Video Preview
LS.Bio.6.2: : Construct an explanation to summarize how inheritable genetic variations may result from: new genetic combinations in meiosis, mutations during replication, or mutations caused by environmental factors.
Building DNA
Construct a DNA molecule, examine its double-helix structure, and then go through the DNA replication process. Learn how each component fits into a DNA molecule, and see how a unique, self-replicating code can be created. 5 Minute Preview
Evolution: Mutation and Selection
Observe evolution in a fictional population of bugs. Set the background to any color, and see natural selection taking place. Inheritance of color occurs according to Mendel's laws and probability. Mutations occur at random, and probability of capture by predators is determined by the insect's camouflage. 5 Minute Preview
Meiosis
Explore how sex cells are produced by the process of meiosis. Compare meiosis in male and female germ cells, and use crossovers to increase the number of possible gamete genotypes. Using meiosis and crossovers, create "designer" fruit fly offspring with desired trait combinations. 5 Minute Preview
Meowsis - High School
As a geneticist in an animal hospital, students learn about genetic changes in meiosis to determine the reason why a male cat can have calico fur coloring. Video Preview
LS.Bio.7: : Understand types of inheritance and how the environment can influence traits.
LS.Bio.7.1: : Use mathematics and computational thinking to predict the variation and distribution of expressed traits based on: Mendelian inheritance, co-dominance, incomplete dominance, multiple alleles, and sex-linked inheritance.
Chicken Genetics
Breed "pure" chickens with known genotypes that exhibit specific feather colors, and learn how traits are passed on via codominant genes. Chickens can be stored in cages for future breeding, and the statistics of feather color are reported every time the chickens breed. Punnett squares can be used to predict results. 5 Minute Preview
Fast Plants® 1 - Growth and Genetics
Grow Wisconsin Fast Plants® in a simulated lab environment. Explore the life cycles of these plants and how their growth is influenced by light, water, and crowding. Practice pollinating the plants using bee sticks, then observe the traits of the offspring plants. Use Punnett squares to model the inheritance of genes for stem color and leaf color for these plants. 5 Minute Preview
Fast Plants® 2 - Mystery Parent
In this follow-up to Fast Plants® 1 - Growth and Genetics, continue to explore inheritance of traits in Wisconsin Fast Plants. Infer the genotype of a "mystery P2 parent" of a set of Fast Plants based on the traits of the P1, F1, and F2 plants. Then create designer Fast Plants by selectively breeding plants with desired traits. 5 Minute Preview
Human Karyotyping
Sort and pair the images of human chromosomes obtained in a scan. Find differences in the scans of the various patients to find out specific things that can cause disease, as well as determining the sex of the person. 5 Minute Preview
Microevolution
Observe the effect of predators on a population of parrots with three possible genotypes. The initial percentages and fitness levels of each genotype can be set. Determine how initial fitness levels affect genotype and allele frequencies through several generations. Compare scenarios in which a dominant allele is deleterious, a recessive allele is deleterious, and the heterozygous individual is fittest. 5 Minute Preview
Mouse Genetics (One Trait)
Breed "pure" mice with known genotypes that exhibit specific fur colors, and learn how traits are passed on via dominant and recessive genes. Mice can be stored in cages for future breeding, and the statistics of fur color are reported every time a pair of mice breed. Punnett squares can be used to predict results. 5 Minute Preview
Mouse Genetics (Two Traits)
Breed "pure" mice with known genotypes that exhibit specific fur and eye colors, and learn how traits are passed on via dominant and recessive genes. Mice can be stored in cages for future breeding, and the statistics of fur and eye color are reported every time a pair of mice breed. Punnett squares can be used to predict results. 5 Minute Preview
LS.Bio.7.3: : Construct an explanation to summarize how traits result from interactions of genetic factors (multiple genes and/or alleles) and environmental factors.
Evolution: Mutation and Selection
Observe evolution in a fictional population of bugs. Set the background to any color, and see natural selection taking place. Inheritance of color occurs according to Mendel's laws and probability. Mutations occur at random, and probability of capture by predators is determined by the insect's camouflage. 5 Minute Preview
LS.Bio.8: : Understand applications of genetics and biotechnology.
LS.Bio.8.1: : Analyze and interpret data to compare DNA samples.
DNA Analysis
Scan the DNA of frogs to produce DNA sequences. Use the DNA sequences to identify possible identical twins and to determine which sections of DNA code for skin color, eye color, and the presence or absence of spots. 5 Minute Preview
DNA Profiling
Learn how DNA is compared to identify individuals. Identify the sections of DNA that tend to differ and use PCR to amplify these segments. Then use gel electrophoresis to create DNA profiles. Based on what you have learned, create your own DNA profiling test and use this test to analyze crime scene evidence. 5 Minute Preview
LS.Bio.8.2: : Obtain and communicate information that summarizes the impact of biotechnology applications on the individual, society, and the environment, including agriculture and medicine.
DNA Profiling
Learn how DNA is compared to identify individuals. Identify the sections of DNA that tend to differ and use PCR to amplify these segments. Then use gel electrophoresis to create DNA profiles. Based on what you have learned, create your own DNA profiling test and use this test to analyze crime scene evidence. 5 Minute Preview
GMOs and the Environment
In this follow-up to the Genetic Engineering Gizmo, explore how farmers can maximize yield while limiting ecosystem damage using genetically modified corn. Choose the corn type to plant and the amount of herbicide and insecticide to use, then measure corn yields and monitor wildlife populations and diversity. Observe the long-term effects of pollutants on a nearby stream ecosystem. 5 Minute Preview
Genetic Engineering
Use genetic engineering techniques to create corn plants resistant to insect pests or tolerant of herbicides. Identify useful genes from bacteria, insert the desired gene into a corn plant, and then compare the modified plant to a control plant in a lab setting. 5 Minute Preview
4: : Biological Evolution- Unity and Diversity
LS.Bio.9: : Understand natural selection as a mechanism for biological evolution.
LS.Bio.9.1: : Analyze and interpret data to summarize how various factors such as geographic isolation, pesticide resistance, antibiotic resistance can influence natural selection.
Evolution - High School
Working as a CDC researcher, students investigate an outbreak of multi-drug resistant bacterial infections and determine how evolution was involved by tracing the source and cause of the outbreak. Video Preview
LS.Bio.9.2: : Construct an explanation to illustrate how common ancestry and biological evolution are supported by multiple lines of empirical evidence.
Cladograms
Based on the similarities and differences between different organisms, create branching diagrams called cladograms to show how they are related. Use both morphological data (physical traits) and molecular data to create the simplest and most likely cladograms. Five different sets of organisms are available. 5 Minute Preview
Embryo Development
Explore how a fertilized cell develops into an embryo, a fetus, and eventually an adult organism. Compare embryo development in different vertebrate species and try to guess which embryo belongs to each species. Use dyes to trace the differentiation of cells during early embryo development, from the zygote to the neurula. 5 Minute Preview
Human Evolution - Skull Analysis
Compare the skulls of a variety of significant human ancestors, or hominids. Use available tools to measure lengths, areas, and angles of important features. Each skull can be viewed from the front, side, or from below. Additional information regarding the age, location, and discoverer of each skull can be displayed. 5 Minute Preview
Natural Selection
You are a bird hunting moths (both dark and light) that live on trees. As you capture the moths most easily visible against the tree surface, the moth populations change, illustrating the effects of natural selection. 5 Minute Preview
RNA and Protein Synthesis
Go through the process of synthesizing proteins through RNA transcription and translation. Learn about the many steps involved in protein synthesis including: unzipping of DNA, formation of mRNA, attaching of mRNA to the ribosome, and linking of amino acids to form a protein. 5 Minute Preview
Rainfall and Bird Beaks
Study the thickness of birds' beaks over a five-year period as you control the yearly rainfall on an isolated island. As the environmental conditions change, the species must adapt (a real-world consequence) to avoid extinction. 5 Minute Preview
Rainfall and Bird Beaks - Metric
Study the thickness of birds' beaks over a five year period as you control the yearly rainfall on an isolated island. As the environmental conditions change, the species must adapt (a real-world consequence) to avoid extinction. 5 Minute Preview
LS.Bio.9.3: : Use models to illustrate the conditions required for natural selection, including the overproduction of offspring, inherited variation, and the struggle to survive.
Evolution: Mutation and Selection
Observe evolution in a fictional population of bugs. Set the background to any color, and see natural selection taking place. Inheritance of color occurs according to Mendel's laws and probability. Mutations occur at random, and probability of capture by predators is determined by the insect's camouflage. 5 Minute Preview
Evolution: Natural and Artificial Selection
Observe evolution in a fictional population of bugs. Set the background to any color, and see natural selection taking place. Compare the processes of natural and artificial selection. Manipulate the mutation rate, and determine how mutation rate affects adaptation and evolution. 5 Minute Preview
Evolution - High School
Working as a CDC researcher, students investigate an outbreak of multi-drug resistant bacterial infections and determine how evolution was involved by tracing the source and cause of the outbreak. Video Preview
LS.Bio.9.4: : Construct an explanation to explain how natural selection leads to adaptations within populations.
Evolution: Mutation and Selection
Observe evolution in a fictional population of bugs. Set the background to any color, and see natural selection taking place. Inheritance of color occurs according to Mendel's laws and probability. Mutations occur at random, and probability of capture by predators is determined by the insect's camouflage. 5 Minute Preview
Microevolution
Observe the effect of predators on a population of parrots with three possible genotypes. The initial percentages and fitness levels of each genotype can be set. Determine how initial fitness levels affect genotype and allele frequencies through several generations. Compare scenarios in which a dominant allele is deleterious, a recessive allele is deleterious, and the heterozygous individual is fittest. 5 Minute Preview
Natural Selection
You are a bird hunting moths (both dark and light) that live on trees. As you capture the moths most easily visible against the tree surface, the moth populations change, illustrating the effects of natural selection. 5 Minute Preview
Evolution - High School
Working as a CDC researcher, students investigate an outbreak of multi-drug resistant bacterial infections and determine how evolution was involved by tracing the source and cause of the outbreak. Video Preview
LS.Bio.10: : Analyze evolutionary relationships among organisms.
LS.Bio.10.1: : Construct explanations to illustrate how varying environmental conditions may result in: changes in the number of individuals of a species, the emergence of new species over time, or the extinction of other species.
Natural Selection
You are a bird hunting moths (both dark and light) that live on trees. As you capture the moths most easily visible against the tree surface, the moth populations change, illustrating the effects of natural selection. 5 Minute Preview
Rainfall and Bird Beaks
Study the thickness of birds' beaks over a five-year period as you control the yearly rainfall on an isolated island. As the environmental conditions change, the species must adapt (a real-world consequence) to avoid extinction. 5 Minute Preview
Rainfall and Bird Beaks - Metric
Study the thickness of birds' beaks over a five year period as you control the yearly rainfall on an isolated island. As the environmental conditions change, the species must adapt (a real-world consequence) to avoid extinction. 5 Minute Preview
Evolution - High School
Working as a CDC researcher, students investigate an outbreak of multi-drug resistant bacterial infections and determine how evolution was involved by tracing the source and cause of the outbreak. Video Preview
LS.Bio.10.2: : Use models (including dichotomous keys, scientific nomenclature, cladograms, phylogenetic trees) to identify organisms and exemplify relationships.
Cladograms
Based on the similarities and differences between different organisms, create branching diagrams called cladograms to show how they are related. Use both morphological data (physical traits) and molecular data to create the simplest and most likely cladograms. Five different sets of organisms are available. 5 Minute Preview
Dichotomous Keys
Use dichotomous keys to identify and classify five types of organisms: California albatrosses, Canadian Rockies buttercups, Texas venomous snakes, Virginia evergreens, and Florida cartilagenous fishes. After you have classified every organism, try making your own dichotomous key! 5 Minute Preview
Correlation last revised: 10/12/2023
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