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- Science: Biology I
Tennessee - Science: Biology I
Academic Standards | Adopted: 2022
BIO1.LS1: : From Molecules to Organisms: Structures and Processes
BIO1.LS1.1: : Construct an explanation based on evidence that the essential functions of life are primarily carried out through the work of proteins that are coded for by genes in DNA, as described by the Central Dogma (i.e., transcription, translation).

Building DNA
Construct a DNA molecule, examine its double-helix structure, and then go through the DNA replication process. Learn how each component fits into a DNA molecule, and see how a unique, self-replicating code can be created. 5 Minute Preview

RNA and Protein Synthesis
Go through the process of synthesizing proteins through RNA transcription and translation. Learn about the many steps involved in protein synthesis including: unzipping of DNA, formation of mRNA, attaching of mRNA to the ribosome, and linking of amino acids to form a protein. 5 Minute Preview

Protein Synthesis - High School
As a pediatrician, students learn about genes and protein synthesis to try to help a baby girl named Lucy who has an immunodeficiency disease. Video Preview
BIO1.LS1.2: : Plan and conduct an investigation to provide evidence that feedback mechanisms maintain homeostasis.

Homeostasis
Control a simulated person running on a treadmill. Your challenge is to use clothing, exercise, and sweat to maintain a constant body temperature as air temperature goes up and down. Sweating (perspiration) can be controlled automatically by the Gizmo or, for a challenge, manually by the user. Don't forget to eat and drink! 5 Minute Preview

Human Homeostasis
Adjust the levels of clothing, perspiration, and exercise to maintain a stable internal temperature as the external temperature changes. Water and blood sugar levels need to be replenished regularly, and fatigue occurs with heavy exercise. Severe hypothermia, heat stroke, or dehydration can result if internal stability is not maintained. 5 Minute Preview

Enzymes - High School
As a veterinary technician, students learn about enzymes to help a dog that has been eating normally but is losing a lot of weight. Video Preview

Homeostasis - High School
In the role of a physician assistant, students help a young man, named Anthony, who has Type II diabetes and high blood pressure. Students must make a diagnosis and then must apply the principles of filtration and homeostasis to help Anthony. Video Preview
BIO1.LS1.3: : Use a model to describe how differentiation in a multicellular organism creates specialized cells that perform diverse functions to work together to meet the needs of the entire organism, including human development.

Cell Division
Begin with a single cell and watch as mitosis and cell division occurs. The cells will go through the steps of interphase, prophase, metaphase, anaphase, telophase, and cytokinesis. The length of the cell cycle can be controlled, and data related to the number of cells present and their current phase can be recorded. 5 Minute Preview

Embryo Development
Explore how a fertilized cell develops into an embryo, a fetus, and eventually an adult organism. Compare embryo development in different vertebrate species and try to guess which embryo belongs to each species. Use dyes to trace the differentiation of cells during early embryo development, from the zygote to the neurula. 5 Minute Preview
BIO1.LS1.4: : Create, or use, a model to describe how the process of photosynthesis converts light energy into the stored chemical energy of bonds created by converting CO? and H?O into sugar and other organic molecules.

Cell Energy Cycle
Explore the processes of photosynthesis and respiration that occur within plant and animal cells. The cyclical nature of the two processes can be constructed visually, and the simplified photosynthesis and respiration formulae can be balanced. 5 Minute Preview

Photosynthesis Lab
Study photosynthesis in a variety of conditions. Oxygen production is used to measure the rate of photosynthesis. Light intensity, carbon dioxide levels, temperature, and wavelength of light can all be varied. Determine which conditions are ideal for photosynthesis, and understand how limiting factors affect oxygen production. 5 Minute Preview

Photosynthesis - High School
As a marine biologist students learn about photosynthesis to help scientists in Australia determine why the coral in the Great Barrier Reef is bleaching. Video Preview
BIO1.LS1.5: : Construct an explanation based on evidence that matter taken into an organism can be broken down and recombined to make macromolecules necessary for life functions.

Dehydration Synthesis
Build a glucose molecule, atom-by-atom, to learn about chemical bonds and the structure of glucose. Explore the processes of dehydration synthesis and hydrolysis in carbohydrate molecules. 5 Minute Preview
BIO1.LS1.6: : Create, or use, a model to describe how cellular respiration transforms stored chemical energy of food resulting in a net transfer of energy. Compare aerobic respiration to alternative processes of glucose metabolism.

Cell Energy Cycle
Explore the processes of photosynthesis and respiration that occur within plant and animal cells. The cyclical nature of the two processes can be constructed visually, and the simplified photosynthesis and respiration formulae can be balanced. 5 Minute Preview

Cell Respiration - High School
As a medical toxicologist, students learn about cell respiration to save the life of a CIA agent that has been poisoned. Video Preview
BIO1.LS1.7: : Construct an explanation from evidence to explain how the integrated functions of the brain in complex animals results in successful interpretation of input and generation of behaviors in response to those inputs.

Eyes and Vision 2 - Focusing Light
Once light enters the eye, it must be focused on the retina. Manipulate the pupil diameter to regulate the amount of light that enters then eye, then change the lens shape to focus light. Determine the changes in lens shape needed to maintain focus as the object distance changes. This is a followup to the Eyes and Vision 1 - Seeing Colors lesson. 5 Minute Preview

Eyes and Vision 3 - Sensing Light
Observe how photoreceptors on the retina are stimulated by different colors of light. Determine that cone cells are stimulated by specific colors of light and enable us to see color, while rod cells are stimulated by various colors and do not contribute to color vision. Experiment by varying the percentage of rod and cone cells in normal and dim light to see how rod cells help with night vision. 5 Minute Preview

Senses
Everything we know about the world comes through our senses: sight, hearing, touch, taste, and smell. In the Senses Gizmo, explore how stimuli are detected by specialized cells, transmitted through nerves, and processed in the brain. 5 Minute Preview

Sight vs. Sound Reactions
Measure your reaction time by clicking your mouse as quickly as possible when visual or auditory stimuli are presented. The individual response times are recorded, as well as the mean and standard deviation for each test. A histogram of data shows overall trends in sight and sound response times. The type of test as well as the symbols and sounds used are chosen by the user. 5 Minute Preview
BIO1.LS2: : Ecosystems: Interactions, Energy, and Dynamics
BIO1.LS2.1: : Use mathematical and/or computational representations to support explanations of factors that affect carrying capacity of ecosystems at different scales.

Food Chain
In this ecosystem consisting of hawks, snakes, rabbits and grass, the population of each species can be studied as part of a food chain. Disease can be introduced for any species, and the number of animals can be increased or decreased at any time, just like in the real world. 5 Minute Preview

Forest Ecosystem
Observe and manipulate the populations of four creatures (trees, deer, bears, and mushrooms) in a forest. Investigate the feeding relationships (food web) in the forest. Determine which creatures are producers, consumers, and decomposers. Pictographs and line graphs show changes in populations over time. 5 Minute Preview

Prairie Ecosystem
Observe the populations of grass, prairie dogs, ferrets and foxes in a prairie ecosystem. Investigate feeding relationships and determine the food chain. Bar graphs and line graphs show changes in populations over time. 5 Minute Preview

Rabbit Population by Season
Observe the population of rabbits in an environment over many years. The land available to the rabbits and weather conditions can be adjusted to investigate the effects of urban sprawl and unusual weather on wildlife populations. 5 Minute Preview

Rainfall and Bird Beaks
Study the thickness of birds' beaks over a five-year period as you control the yearly rainfall on an isolated island. As the environmental conditions change, the species must adapt (a real-world consequence) to avoid extinction. 5 Minute Preview

Rainfall and Bird Beaks - Metric
Study the thickness of birds' beaks over a five year period as you control the yearly rainfall on an isolated island. As the environmental conditions change, the species must adapt (a real-world consequence) to avoid extinction. 5 Minute Preview

Ecosystems - High School
As a national park ranger, students must restore the ecosystem of a park back to normal. They interact with populations of many organisms including wolves, deer and bees. Students learn the importance of food chains and webs, and how human factors can impact the health of an environment. Video Preview
BIO1.LS2.2: : Create, or use, a mathematical model to describe the transfer of energy from one trophic level to another. Explain how the inefficiency of energy transfer between trophic levels affects the relative number of organisms that can be supported at each trophic level and necessitates a constant input of energy from sunlight and inorganic compounds from the environment.

Ecosystems - High School
As a national park ranger, students must restore the ecosystem of a park back to normal. They interact with populations of many organisms including wolves, deer and bees. Students learn the importance of food chains and webs, and how human factors can impact the health of an environment. Video Preview
BIO1.LS2.3: : Obtain, evaluate, and communicate information based on evidence to describe how the impact of varying levels of disturbance is related to the resilience of an ecosystem.

Coral Reefs 2 - Biotic Factors
In this followup to the Coral Reefs 1 - Abiotic Factors activity, investigate the impacts of fishing, disease, and invasive species on a model Caribbean coral reef. Many variables can be manipulated, included intensity of fishing, presence of black band and white band disease, and the presence of actual and potential invasive species. Click "Advance year" to see the impacts of these biotic changes. 5 Minute Preview

Food Chain
In this ecosystem consisting of hawks, snakes, rabbits and grass, the population of each species can be studied as part of a food chain. Disease can be introduced for any species, and the number of animals can be increased or decreased at any time, just like in the real world. 5 Minute Preview

Prairie Ecosystem
Observe the populations of grass, prairie dogs, ferrets and foxes in a prairie ecosystem. Investigate feeding relationships and determine the food chain. Bar graphs and line graphs show changes in populations over time. 5 Minute Preview

Ecosystems - High School
As a national park ranger, students must restore the ecosystem of a park back to normal. They interact with populations of many organisms including wolves, deer and bees. Students learn the importance of food chains and webs, and how human factors can impact the health of an environment. Video Preview
BIO1.LS2.4: : Design, evaluate, and refine a solution for reducing the impacts of human activities on the environment and biodiversity.

GMOs and the Environment
In this follow-up to the Genetic Engineering Gizmo, explore how farmers can maximize yield while limiting ecosystem damage using genetically modified corn. Choose the corn type to plant and the amount of herbicide and insecticide to use, then measure corn yields and monitor wildlife populations and diversity. Observe the long-term effects of pollutants on a nearby stream ecosystem. 5 Minute Preview

Nitrogen Cycle - High School
An infant on a farm has blue baby syndrome. As an EPA environmental engineer, students must find the cause of the baby's illness. Using environment data, students learn the importance of the nitrogen cycle and how human factors can impact nature. Video Preview

Photosynthesis - High School
As a marine biologist students learn about photosynthesis to help scientists in Australia determine why the coral in the Great Barrier Reef is bleaching. Video Preview
BIO1.LS3: : Heredity: Inheritance and Variation of Traits
BIO1.LS3.1: : Engage in an argument from evidence that the process of cellular division (mitosis) creates diploid daughter cells that are genetically identical to the diploid parent cells.

Cell Division
Begin with a single cell and watch as mitosis and cell division occurs. The cells will go through the steps of interphase, prophase, metaphase, anaphase, telophase, and cytokinesis. The length of the cell cycle can be controlled, and data related to the number of cells present and their current phase can be recorded. 5 Minute Preview
BIO1.LS3.2: : Engage in an argument from evidence that the process of meiosis exists to create genetic variation in a population from the creation of new combinations of genetic material in each of the haploid gametes.

Meiosis
Explore how sex cells are produced by the process of meiosis. Compare meiosis in male and female germ cells, and use crossovers to increase the number of possible gamete genotypes. Using meiosis and crossovers, create "designer" fruit fly offspring with desired trait combinations. 5 Minute Preview

Meowsis - High School
As a geneticist in an animal hospital, students learn about genetic changes in meiosis to determine the reason why a male cat can have calico fur coloring. Video Preview
BIO1.LS3.3: : Ask questions to clarify that variation of traits arises from differences in genes (alleles) and how cells regulate gene expression.

DNA Analysis
Scan the DNA of frogs to produce DNA sequences. Use the DNA sequences to identify possible identical twins and to determine which sections of DNA code for skin color, eye color, and the presence or absence of spots. 5 Minute Preview

DNA Profiling
Learn how DNA is compared to identify individuals. Identify the sections of DNA that tend to differ and use PCR to amplify these segments. Then use gel electrophoresis to create DNA profiles. Based on what you have learned, create your own DNA profiling test and use this test to analyze crime scene evidence. 5 Minute Preview

Genetic Engineering
Use genetic engineering techniques to create corn plants resistant to insect pests or tolerant of herbicides. Identify useful genes from bacteria, insert the desired gene into a corn plant, and then compare the modified plant to a control plant in a lab setting. 5 Minute Preview

Human Karyotyping
Sort and pair the images of human chromosomes obtained in a scan. Find differences in the scans of the various patients to find out specific things that can cause disease, as well as determining the sex of the person. 5 Minute Preview

Meiosis
Explore how sex cells are produced by the process of meiosis. Compare meiosis in male and female germ cells, and use crossovers to increase the number of possible gamete genotypes. Using meiosis and crossovers, create "designer" fruit fly offspring with desired trait combinations. 5 Minute Preview

RNA and Protein Synthesis
Go through the process of synthesizing proteins through RNA transcription and translation. Learn about the many steps involved in protein synthesis including: unzipping of DNA, formation of mRNA, attaching of mRNA to the ribosome, and linking of amino acids to form a protein. 5 Minute Preview

Meowsis - High School
As a geneticist in an animal hospital, students learn about genetic changes in meiosis to determine the reason why a male cat can have calico fur coloring. Video Preview
BIO1.LS3.4: : Construct an explanation based on evidence that genetic variations may result from (a) new genetic combinations via the processes of crossing over and random segregation of chromosomes during meiosis, (b) mutations that occur during replication, and/or (c) mutations caused by environmental factors. Evidence should include that mutations that occur in gametes can be passed to offspring.

Building DNA
Construct a DNA molecule, examine its double-helix structure, and then go through the DNA replication process. Learn how each component fits into a DNA molecule, and see how a unique, self-replicating code can be created. 5 Minute Preview

Evolution: Mutation and Selection
Observe evolution in a fictional population of bugs. Set the background to any color, and see natural selection taking place. Inheritance of color occurs according to Mendel's laws and probability. Mutations occur at random, and probability of capture by predators is determined by the insect's camouflage. 5 Minute Preview

Meiosis
Explore how sex cells are produced by the process of meiosis. Compare meiosis in male and female germ cells, and use crossovers to increase the number of possible gamete genotypes. Using meiosis and crossovers, create "designer" fruit fly offspring with desired trait combinations. 5 Minute Preview

Meowsis - High School
As a geneticist in an animal hospital, students learn about genetic changes in meiosis to determine the reason why a male cat can have calico fur coloring. Video Preview
BIO1.LS4: : Biological Change: Unity and Diversity
BIO1.LS4.1: : Analyze and interpret scientific data that common ancestry and biological evolution are supported by multiple lines of empirical evidence (e.g., DNA sequences, amino acid sequences, anatomical structures, the fossil record, biogeography, or order of appearance of structures during embryological development).

Cladograms
Based on the similarities and differences between different organisms, create branching diagrams called cladograms to show how they are related. Use both morphological data (physical traits) and molecular data to create the simplest and most likely cladograms. Five different sets of organisms are available. 5 Minute Preview

Embryo Development
Explore how a fertilized cell develops into an embryo, a fetus, and eventually an adult organism. Compare embryo development in different vertebrate species and try to guess which embryo belongs to each species. Use dyes to trace the differentiation of cells during early embryo development, from the zygote to the neurula. 5 Minute Preview

Evolution: Natural and Artificial Selection
Observe evolution in a fictional population of bugs. Set the background to any color, and see natural selection taking place. Compare the processes of natural and artificial selection. Manipulate the mutation rate, and determine how mutation rate affects adaptation and evolution. 5 Minute Preview

Human Evolution - Skull Analysis
Compare the skulls of a variety of significant human ancestors, or hominids. Use available tools to measure lengths, areas, and angles of important features. Each skull can be viewed from the front, side, or from below. Additional information regarding the age, location, and discoverer of each skull can be displayed. 5 Minute Preview

Natural Selection
You are a bird hunting moths (both dark and light) that live on trees. As you capture the moths most easily visible against the tree surface, the moth populations change, illustrating the effects of natural selection. 5 Minute Preview

RNA and Protein Synthesis
Go through the process of synthesizing proteins through RNA transcription and translation. Learn about the many steps involved in protein synthesis including: unzipping of DNA, formation of mRNA, attaching of mRNA to the ribosome, and linking of amino acids to form a protein. 5 Minute Preview

Rainfall and Bird Beaks
Study the thickness of birds' beaks over a five-year period as you control the yearly rainfall on an isolated island. As the environmental conditions change, the species must adapt (a real-world consequence) to avoid extinction. 5 Minute Preview

Rainfall and Bird Beaks - Metric
Study the thickness of birds' beaks over a five year period as you control the yearly rainfall on an isolated island. As the environmental conditions change, the species must adapt (a real-world consequence) to avoid extinction. 5 Minute Preview
BIO1.LS4.2: : Apply concepts of statistics (i.e., probability) to support explanations that organisms in a population with an advantageous heritable trait tend to increase in proportion to organisms lacking this trait.

Evolution: Mutation and Selection
Observe evolution in a fictional population of bugs. Set the background to any color, and see natural selection taking place. Inheritance of color occurs according to Mendel's laws and probability. Mutations occur at random, and probability of capture by predators is determined by the insect's camouflage. 5 Minute Preview

Microevolution
Observe the effect of predators on a population of parrots with three possible genotypes. The initial percentages and fitness levels of each genotype can be set. Determine how initial fitness levels affect genotype and allele frequencies through several generations. Compare scenarios in which a dominant allele is deleterious, a recessive allele is deleterious, and the heterozygous individual is fittest. 5 Minute Preview

Rainfall and Bird Beaks
Study the thickness of birds' beaks over a five-year period as you control the yearly rainfall on an isolated island. As the environmental conditions change, the species must adapt (a real-world consequence) to avoid extinction. 5 Minute Preview

Rainfall and Bird Beaks - Metric
Study the thickness of birds' beaks over a five year period as you control the yearly rainfall on an isolated island. As the environmental conditions change, the species must adapt (a real-world consequence) to avoid extinction. 5 Minute Preview

Evolution - High School
Working as a CDC researcher, students investigate an outbreak of multi-drug resistant bacterial infections and determine how evolution was involved by tracing the source and cause of the outbreak. Video Preview
BIO1.LS4.3: : Analyze and interpret data that natural selection is influenced by (1) the potential for a species to increase in number, (2) the heritable genetic variation of individuals in a species due to mutation and sexual reproduction, (3) competition for limited resources, and (4) the proliferation of those organisms that are better able to survive and reproduce in the environment.

Evolution: Mutation and Selection
Observe evolution in a fictional population of bugs. Set the background to any color, and see natural selection taking place. Inheritance of color occurs according to Mendel's laws and probability. Mutations occur at random, and probability of capture by predators is determined by the insect's camouflage. 5 Minute Preview

Natural Selection
You are a bird hunting moths (both dark and light) that live on trees. As you capture the moths most easily visible against the tree surface, the moth populations change, illustrating the effects of natural selection. 5 Minute Preview

Rainfall and Bird Beaks
Study the thickness of birds' beaks over a five-year period as you control the yearly rainfall on an isolated island. As the environmental conditions change, the species must adapt (a real-world consequence) to avoid extinction. 5 Minute Preview

Rainfall and Bird Beaks - Metric
Study the thickness of birds' beaks over a five year period as you control the yearly rainfall on an isolated island. As the environmental conditions change, the species must adapt (a real-world consequence) to avoid extinction. 5 Minute Preview

Evolution - High School
Working as a CDC researcher, students investigate an outbreak of multi-drug resistant bacterial infections and determine how evolution was involved by tracing the source and cause of the outbreak. Video Preview
BIO1.LS4.4: : Construct an explanation based on evidence for how natural selection leads to adaptation in populations.

Evolution: Mutation and Selection
Observe evolution in a fictional population of bugs. Set the background to any color, and see natural selection taking place. Inheritance of color occurs according to Mendel's laws and probability. Mutations occur at random, and probability of capture by predators is determined by the insect's camouflage. 5 Minute Preview

Microevolution
Observe the effect of predators on a population of parrots with three possible genotypes. The initial percentages and fitness levels of each genotype can be set. Determine how initial fitness levels affect genotype and allele frequencies through several generations. Compare scenarios in which a dominant allele is deleterious, a recessive allele is deleterious, and the heterozygous individual is fittest. 5 Minute Preview

Natural Selection
You are a bird hunting moths (both dark and light) that live on trees. As you capture the moths most easily visible against the tree surface, the moth populations change, illustrating the effects of natural selection. 5 Minute Preview

Evolution - High School
Working as a CDC researcher, students investigate an outbreak of multi-drug resistant bacterial infections and determine how evolution was involved by tracing the source and cause of the outbreak. Video Preview
BIO1.LS4.5: : Obtain, evaluate, and communicate information about how changes in environmental conditions may result in (1) increases in the number of individuals of some species, (2) the emergence of new species over time, and (3) the extinction of other species.

Coral Reefs 1 - Abiotic Factors
Explore the abiotic factors that affect Caribbean coral reefs. Many factors can be manipulated in this simplified reef model, including ocean temperature and pH, storm severity, and input of excess sediments and nutrients from logging, sewage, and agriculture. Click "Advance year" to see how the reef responds to these changes. 5 Minute Preview

Coral Reefs 2 - Biotic Factors
In this followup to the Coral Reefs 1 - Abiotic Factors activity, investigate the impacts of fishing, disease, and invasive species on a model Caribbean coral reef. Many variables can be manipulated, included intensity of fishing, presence of black band and white band disease, and the presence of actual and potential invasive species. Click "Advance year" to see the impacts of these biotic changes. 5 Minute Preview

Rabbit Population by Season
Observe the population of rabbits in an environment over many years. The land available to the rabbits and weather conditions can be adjusted to investigate the effects of urban sprawl and unusual weather on wildlife populations. 5 Minute Preview

Rainfall and Bird Beaks
Study the thickness of birds' beaks over a five-year period as you control the yearly rainfall on an isolated island. As the environmental conditions change, the species must adapt (a real-world consequence) to avoid extinction. 5 Minute Preview

Rainfall and Bird Beaks - Metric
Study the thickness of birds' beaks over a five year period as you control the yearly rainfall on an isolated island. As the environmental conditions change, the species must adapt (a real-world consequence) to avoid extinction. 5 Minute Preview

Evolution - High School
Working as a CDC researcher, students investigate an outbreak of multi-drug resistant bacterial infections and determine how evolution was involved by tracing the source and cause of the outbreak. Video Preview
Correlation last revised: 5/19/2025
About STEM Cases
Students assume the role of a scientist trying to solve a real world problem. They use scientific practices to collect and analyze data, and form and test a hypothesis as they solve the problems.

Each STEM Case uses realtime reporting to show live student results.
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